Development and Validation of Vilazodone Hcl by Rp-Hplc In Bulk and in Pharmaceutical Formulation Along with its Application in Dissolution

Vilazodone HCl (VLN) is chemically 5-(4-[4-(5-cyano-1Hindol-3-yl) butyl] piperazin-1-yl) benzofuran-2-carboxamide hydrochloride [1] (Figure 1). It contains an indole piperazine that utilizes its function as an SSRI and 5-HT1a receptor partial agonist [2]. It belongs to the category of serotonergic antidepressant approved by FDA (Food and Drug Administration) for treatment of depressive disorder [3]. It is a serotonin reuptake inhibitor and serotonin 1A receptor partial agonist having strong affinity for D2 dopaminergic receptors [4]. It has actions at several 5-HT (serotonin) receptor subtypes. The extensive literature Abstract